The Anticentromere Antibody (ACA) test is a blood test used to detect the presence of specific antibodies in the bloodstream. These antibodies, known as anticentromere antibodies, are associated with certain autoimmune diseases, particularly systemic sclerosis (scleroderma). ACA antibodies target structures within the cell called centromeres. The test helps in the diagnosis and monitoring of autoimmune conditions affecting the skin and internal organs.