KRAS Mutation Test For Colorectal and Lung Cancers

The KRAS mutation test is a medical examination that identifies specific genetic alterations in the KRAS gene. It helps determine whether certain cancer treatments will be effective, particularly in cases of colorectal and lung cancers, as KRAS mutations can impact treatment decisions.

KRAS Mutation Test

Here are the basic details of the KRAS Mutation Test.

Also Known As	KRAS Test
Type	Molecular genetic test
Purpose	Detect KRAS gene mutations
Sample Type	Tissue or blood
Preparation	No specific preparation
Fasting	Fasting not required
Gender	All
Age Group	All
Normal Value	Negative (No KRS Mutation)
Reporting Time	Few Days to week
Cost	10,000-20,000 INR*

*KRAS Mutation Test Price range may vary as per location, lab type, and procedure of lab test.

KRAS Mutation Test Means

KRAS Mutation Test is a Molecular genetic test to detect KRAS gene mutations.

Aids in determining cancer treatment effectiveness.
Can influence treatment decisions in colorectal and lung cancers.
Requires tissue or blood samples.
No specific preparation or fasting is needed.
Timely reporting of mutation status.

KRAS Mutation Test Purpose

The purpose of the KRAS Mutation Test is to:

Molecular genetic test to detect KRAS gene mutations.
Aids in determining cancer treatment effectiveness.
Can influence treatment decisions in colorectal and lung cancers.
Requires tissue or blood samples.
No specific preparation or fasting is needed.
Timely reporting of mutation status.

KRAS Mutation Test Price, Normal Range, Result, Purpose, Procedure Meaning and Interpretation - Drlogy Test

KRAS Mutation Test Preparation

Here is the basic preparation for the KRAS Mutation Test.

Before Test

Discuss any specific instructions with your healthcare provider.
Inform your healthcare provider about any medications or allergies.

During Test

The test can be conducted on a tissue or blood sample.
For a blood sample, a simple blood draw will be performed by a phlebotomist.

After Test

Resume your normal activities immediately.
Await test results, and follow up with your healthcare provider for interpretation and guidance, if required.

KRAS Mutation Test Procedure

Here is the basic KRAS Mutation Test Procedure.

A sample is collected, typically through a blood draw or tissue biopsy.
The sample is sent to the laboratory.
Molecular genetic techniques are used to detect KRAS gene mutations.
Results are provided by your healthcare provider.

KRAS Mutation Test Result

Here is basic meaning of KRAS Mutation Test.

A positive result indicates the presence of KRAS gene mutations.
A negative result suggests the absence of these mutations.
Interpretation of the results will guide treatment decisions in specific cancers.
Discuss your results with your healthcare provider for personalized treatment recommendations.

KRAS Mutation Test Normal Result

Here is the normal result of the KRAS Mutation Test.

KRAS Mutation Test Result	Interpretation
Negative	No KRAS Mutation detected

KRAS Mutation Test Interpretation

Here is the Interpretation of the KRAS Mutation Test.

KRAS Mutation Test Result	Interpretation
Positive	KRAS Mutation detected
Negative	No KRAS Mutation detected

KRAS Mutation Test Positive Results

Here are the potential causes of KRAS Mutation Test Positive Results.

Potential Causes	Information
KRAS Gene Mutation	Presence of a mutation in the KRAS gene within cancer cells, indicating resistance to some targeted therapies.

KRAS Mutation Test Negative Results

Here are the potential causes of KRAS Mutation Test Negative Results.

Potential Causes	Information
Absence of KRAS Mutation	Lack of a specific KRAS gene mutation in tested cancer cells, suggesting potential responsiveness to targeted therapies.
Insufficient Sample	Negative results can occur if the tumor tissue sample was inadequate for testing or if the mutation is present in only a subset of cancer cells.
Other Resistance Mechanisms	A negative result does not guarantee therapy effectiveness, as other resistance mechanisms may exist.

Specimen Requirements For KRAS Mutation Test

Here are the specimen requirements for the KRAS Mutation Test.

Specimen Type	Blood or Tissue
Volume	Four unstained slides and one matching H&E-stained slide at 5 μM or formalin-fixed, paraffin-embedded tissue block
Minimum Volume	Two unstained slides and one matching H&E-stained slide at 5 μM. Samples with >4 mm² and ≥20% tumor content are preferred.
Container	Slides, blocks
Storage Instructions	Maintain the specimen at room temperature for up to 4 weeks at 15-30°C.
Causes for Rejection	Tumor block containing no tumor tissue; tumor fixed in a heavy metal fixative; broken or stained slides.

KRAS Mutation Test is Safe?

KRAS Mutation Test is generally safe, but risks may depend on the sample collection method.

Blood tests are minimally invasive with minimal risks.
Tissue biopsies may carry some risks such as bleeding or infection, but these are rare and typically well managed.

When Do You Get KRAS Mutation Test Results?

KRAS Mutation Test reporting time may vary depending on the specific laboratory.
Generally, you can expect results within a few days to a few weeks, with some tests taking longer for comprehensive analysis.

KRAS Mutation Test Limitation

Here is the basic limitation of KRAS Mutation Test.

Limited to detecting specific KRAS gene mutations, not all genetic alterations.
Test sensitivity can vary, and some mutations may be missed.
Interpretation of results is essential and may differ among healthcare providers.
Test results may not provide a complete picture of treatment effectiveness.
Additional genetic tests may be required for a comprehensive assessment of cancer mutations.

KRAS Mutation Test Risk Factors

Here are some of the risk factors of the KRAS Mutation Test.

Limited to detecting specific KRAS gene mutations, not all genetic alterations.
Variable sensitivity, potentially missing some mutations.
Interpretation of results may differ among healthcare providers.
Test results may not provide a complete assessment of treatment effectiveness.
Additional genetic tests may be needed for a comprehensive evaluation of cancer mutations.

Doctor Recommendations After KRAS Mutation Test Result

Here are the Doctor's recommendations or consult a specialist after the KRAS Mutation Test.

Test Results	Doctor to Consult	Reason to Visit
Positive	Oncologist	Determine alternative treatment options.
Negative	Oncologist	Discuss targeted therapy possibilities.

KRAS Mutation Test Price

Here are the estimated KRAS Mutation Test Prices in India with different top cities:

City	Price Range (INR)*
Mumbai	10,000-20,000
New Delhi	11,000-20,000
Bangalore	10,000-20,000
Hyderabad	11,000-20,000
Kolkata	10,000-20,000
Pune	11,000-20,000
Lucknow	10,000-20,000
Noida	11,000-20,000
Surat	11,000-20,000
Gurugram	10,000-20,000
Patna	11,000-20,000
Chennai	10,000-20,000
Jaipur	11,000-20,000
Ahmedabad	10,000-20,000

*Prices are approximate and vary depending on a specific laboratory or healthcare facility.

Summary

Overall, KRAS Mutation Test identifies specific mutations in the KRAS gene, assisting in tailoring effective treatments for colorectal and lung cancers. Also check Drlogy Test for detailed information about all medical tests for patients, doctors, scholers and medical students.

Reference

KRAS - Wikipedia [1].
The current understanding of KRAS protein structure and dynamics- NIH [2].

5011 Likes

FAQ

What is a KRAS mutation test?

A KRAS mutation test is a diagnostic tool used to identify specific genetic alterations in the KRAS gene. This test is crucial in the management of colorectal and lung cancers, as it helps determine the appropriate treatment approach.

What are the types of KRAS mutations?

There are different types of KRAS mutations, but the two most common are G12D and G12V. These mutations result in changes to the KRAS protein, making it constitutively active and promoting uncontrolled cell growth, a hallmark of cancer.

How is the KRAS mutation test performed?

The test typically involves analyzing a tissue sample from a tumor or a blood sample to identify KRAS mutations. The results provide insights into the genetic makeup of the cancer and guide personalized treatment decisions.

How long does it take to get KRAS mutation test results?

The turnaround time for KRAS mutation test results can vary, but it typically takes a few days to a couple of weeks. The precise duration depends on the laboratory, the type of sample, and the specific testing method used. Discuss the expected timeline with your healthcare provider.

KRAS Mutation Test For Colorectal and Lung Cancers