13 May Holidays

Apple pie is famous for its status as an iconic American dessert, its rich culinary heritage, its associations with comfort and nostalgia, and its widespread popularity and recognition.

National Pie Day is celebrated to honor and appreciate the art of pie-making, as well as the joy and comfort that pies bring to people's lives. The day serves as a way to celebrate the rich culinary tradition of pies and their cultural significance.

National Apple Pie Day is the perfect occasion to savor the flavors of this beloved dessert. Whether you bake from scratch, delve into history with Chaucer's recipe, or support local bakeries, embrace the joy of apple pie and create lasting memories on this special day.

Cornelia de Lange Syndrome (CdLS) is characterized by a wide range of behavioral and developmental features. Individuals with CdLS may exhibit: Developmental delays, Intellectual disabilities, Communication difficulties, Challenging behaviors, Anxiety and self-regulation issues, and feeding difficulties.

Cornelia de Lange Syndrome (CdLS) is primarily caused by genetic mutations or alterations in certain genes. The most commonly affected genes are NIPBL, SMC1A, and SMC3, which play crucial roles in regulating the development and functioning of various body systems. These mutations disrupt normal cellular processes, leading to the characteristic features and symptoms of CdLS. In some cases, the cause of CdLS may be unknown, indicating that other unidentified genetic factors may be involved.